The role of cancer-associated fibroblasts in the stemness of gastric cancer stem cells
نویسندگان
چکیده
Gastric cancer remains one of the leading causes of global cancer mortality worldwide. In recent years, several studies revealed that gastric cancer contain cancer stem cells (CSCs), a unique subpopulation in tumors, which display stem cell properties: the ability to sustain self-renewal and supply cancer cells. CSCs properties are modulated by their microenvironment, called CSC niche. Recent studies revealed that the interactions between CSC and niche play an important role for the progression of gastric cancer. This brief review presents the current development in gastric cancer stem cell study, which will be useful to find novel therapeutic strategies for gastric cancer.
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